Risk assessment of new fava bean cultivars with low content of vicine and convicine (FEVITA beans) in hemizygous male subjects with total G6PD-deficiency

  • Faba Beans

Lead Investigator(s)

Dr. Paolo Arese

Lead Investigator(s) Institution

University of Torino Medical School - Dept. of Genetics, Biology and Biochemistry

Objective

To show that faba beans with low levels of Vicine and Convicine (low V/C faba, FEVITA beans) are non-toxic and non-hemolytic even when ingested in large amounts by highly susceptible, severely G6PD-deficient individuals.

Outcome

In all subjects there was no indication of hemolysis, shown by the constancy of RBC counts, hematocrit level, hemoglobin parametres, percentage of reticulocytes and level of bilirubin, a sensitive indicator of increased hemoglobin liberation and breakdown.

Health

SPG Contribution

$38,000.00

Project Status

Complete

Duration/Timeline of Project (Year to Year)

2010 - 2011